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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HNF4A
All Species:
24.55
Human Site:
Y72
Identified Species:
45
UniProt:
P41235
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P41235
NP_849180.1
474
52785
Y72
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
Chimpanzee
Pan troglodytes
XP_514664
468
51900
E81
T
W
E
S
A
M
A
E
M
R
C
G
S
V
C
Rhesus Macaque
Macaca mulatta
XP_001110097
452
49945
S75
C
K
G
F
F
R
R
S
V
R
K
N
H
M
Y
Dog
Lupus familis
XP_852731
474
52640
Y72
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
Cat
Felis silvestris
Mouse
Mus musculus
P49698
474
52665
Y72
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
Rat
Rattus norvegicus
P22449
474
52693
Y72
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507309
419
46844
T68
A
I
C
G
D
R
A
T
G
K
H
Y
G
A
S
Chicken
Gallus gallus
NP_001026026
454
50607
K72
A
S
S
C
D
G
C
K
G
F
F
R
R
S
V
Frog
Xenopus laevis
Q91766
464
51948
Y72
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
Zebra Danio
Brachydanio rerio
A2T929
430
47452
S72
H
M
N
S
V
S
S
S
E
D
I
K
P
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49866
666
71882
Y116
D
R
A
T
G
K
H
Y
G
A
S
S
C
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O44960
369
41820
P17
S
T
S
T
S
Q
S
P
Q
S
S
S
F
E
N
Sea Urchin
Strong. purpuratus
XP_780389
468
51669
D72
F
C
R
G
C
V
V
D
K
D
K
R
N
Q
C
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
78.6
90.9
98.3
N.A.
95.7
96.1
N.A.
79.5
84.1
80.8
33.7
N.A.
42.4
N.A.
33.9
57.1
Protein Similarity:
100
82.9
91.9
99.1
N.A.
97
97.4
N.A.
84.8
89.8
89.6
51.4
N.A.
54.5
N.A.
49.5
72.3
P-Site Identity:
100
0
0
100
N.A.
100
100
N.A.
6.6
6.6
100
0
N.A.
100
N.A.
20
0
P-Site Similarity:
100
6.6
20
100
N.A.
100
100
N.A.
13.3
13.3
100
6.6
N.A.
100
N.A.
46.6
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
16
0
47
0
8
0
16
0
0
47
0
0
0
8
0
% A
% Cys:
8
8
8
8
8
0
8
0
0
0
8
0
47
0
16
% C
% Asp:
47
0
0
0
16
0
0
8
0
16
0
0
0
47
0
% D
% Glu:
0
0
8
0
0
0
0
8
8
0
0
0
0
8
0
% E
% Phe:
8
0
0
8
8
0
0
0
0
8
8
0
8
0
0
% F
% Gly:
0
0
8
16
47
8
0
0
62
0
0
8
8
0
47
% G
% His:
8
0
0
0
0
0
47
0
0
0
8
0
8
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
8
0
0
0
47
0
8
8
8
16
8
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% L
% Met:
0
8
0
0
0
8
0
0
8
0
0
0
0
8
0
% M
% Asn:
0
0
8
0
0
0
0
0
0
0
0
8
8
0
8
% N
% Pro:
0
0
0
0
0
0
0
8
0
0
0
0
8
8
0
% P
% Gln:
0
0
0
0
0
8
0
0
8
0
0
0
0
8
0
% Q
% Arg:
0
47
8
0
0
16
8
0
0
16
0
16
8
0
0
% R
% Ser:
8
8
16
16
8
8
16
16
0
8
54
54
8
8
8
% S
% Thr:
8
8
0
54
0
0
0
8
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
8
8
0
8
0
0
0
0
8
8
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
0
8
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _